Ontology highlight
ABSTRACT:
SUBMITTER: Kodan A
PROVIDER: S-EPMC6325147 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kodan Atsushi A Yamaguchi Tomohiro T Nakatsu Toru T Matsuoka Keita K Kimura Yasuhisa Y Ueda Kazumitsu K Kato Hiroaki H
Nature communications 20190108 1
P-glycoprotein extrudes a large variety of xenobiotics from the cell, thereby protecting tissues from their toxic effects. The machinery underlying unidirectional multidrug pumping remains unknown, largely due to the lack of high-resolution structural information regarding the alternate conformational states of the molecule. Here we report a pair of structures of homodimeric P-glycoprotein: an outward-facing conformational state with bound nucleotide and an inward-facing apo state, at resolution ...[more]