Ontology highlight
ABSTRACT:
SUBMITTER: Svidritskiy E
PROVIDER: S-EPMC4635039 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Svidritskiy Egor E Korostelev Andrei A AA
Structure (London, England : 1993) 20150924 11
Translation initiation in the P site occasionally occurs at atypical (non-AUG) start codons, including those forming a mismatch in the third (wobble) position. During elongation, however, a pyrimidine-pyrimidine wobble mismatch may trigger a translation quality-control mechanism, whereby the P-site mismatch is thought to perturb the downstream A-site codon or the decoding center, thereby reducing translation fidelity and inducing termination of aberrant translation. We report a crystal structure ...[more]