Ontology highlight
ABSTRACT:
SUBMITTER: Galej WP
PROVIDER: S-EPMC3672837 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Galej Wojciech P WP Oubridge Chris C Newman Andrew J AJ Nagai Kiyoshi K
Nature 20130123 7434
The active centre of the spliceosome consists of an intricate network formed by U5, U2 and U6 small nuclear RNAs, and a pre-messenger-RNA substrate. Prp8, a component of the U5 small nuclear ribonucleoprotein particle, crosslinks extensively with this RNA catalytic core. Here we present the crystal structure of yeast Prp8 (residues 885-2413) in complex with Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor. The structure reveals tightly associated domains of Prp8 resembling a b ...[more]