Ontology highlight
ABSTRACT:
SUBMITTER: Nastasi C
PROVIDER: S-EPMC4635422 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Nastasi Claudia C Candela Marco M Bonefeld Charlotte Menné CM Geisler Carsten C Hansen Morten M Krejsgaard Thorbjørn T Biagi Elena E Andersen Mads Hald MH Brigidi Patrizia P Ødum Niels N Litman Thomas T Woetmann Anders A
Scientific reports 20151106
The gut microbiota is essential for human health and plays an important role in the pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate and propionate, are end-products of microbial fermentation of macronutrients that distribute systemically via the blood. The aim of this study was to investigate the transcriptional response of immature and LPS-matured human monocyte-derived DC to SCFA. Our data revealed distinct effects exerted by each individual SCFA on ...[more]