Ontology highlight
ABSTRACT:
SUBMITTER: Gregorich ZR
PROVIDER: S-EPMC4637236 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Gregorich Zachery R ZR Peng Ying Y Lane Nicole M NM Wolff Jeremy J JJ Wang Sijian S Guo Wei W Guner Huseyin H Doop Justin J Hacker Timothy A TA Ge Ying Y
Journal of molecular and cellular cardiology 20150809
The heart is characterized by a remarkable degree of heterogeneity, the basis of which is a subject of active investigation. Myofilament protein post-translational modifications (PTMs) represent a critical mechanism regulating cardiac contractility, and emerging evidence shows that pathological cardiac conditions induce contractile heterogeneity that correlates with transmural variations in the modification status of myofilament proteins. Nevertheless, whether there exists basal heterogeneity in ...[more]