Ontology highlight
ABSTRACT:
SUBMITTER: Sitaraman D
PROVIDER: S-EPMC4637407 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Sitaraman Divya D Aso Yoshinori Y Rubin Gerald M GM Nitabach Michael N MN
Frontiers in neural circuits 20151109
The Drosophila mushroom body (MB) is an associative learning network that is important for the control of sleep. We have recently identified particular intrinsic MB Kenyon cell (KC) classes that regulate sleep through synaptic activation of particular MB output neurons (MBONs) whose axons convey sleep control signals out of the MB to downstream target regions. Specifically, we found that sleep-promoting KCs increase sleep by preferentially activating cholinergic sleep-promoting MBONs, while wake ...[more]