Ontology highlight
ABSTRACT:
SUBMITTER: Chung J
PROVIDER: S-EPMC4638224 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150701 6246
Lipid transfer between cell membrane bilayers at contacts between the endoplasmic reticulum (ER) and other membranes help to maintain membrane lipid homeostasis. We found that two similar ER integral membrane proteins, oxysterol-binding protein (OSBP)-related protein 5 (ORP5) and ORP8, tethered the ER to the plasma membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) in this membrane. Their OSBP-related domains (ORDs) harbored either ...[more]