Ontology highlight
ABSTRACT:
SUBMITTER: Sohn M
PROVIDER: S-EPMC5940310 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Sohn Mira M Korzeniowski Marek M Zewe James P JP Wills Rachel C RC Hammond Gerald R V GRV Humpolickova Jana J Vrzal Lukas L Chalupska Dominika D Veverka Vaclav V Fairn Gregory D GD Boura Evzen E Balla Tamas T
The Journal of cell biology 20180222 5
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how cells regulate PM PI(4,5)P<sub>2</sub> levels. Here, we show that the phosphatidylinositol 4-phosphate (PI4P)/phosphatidylserine (PS) transfer activity of the endoplasmic reticulum (ER)-resident ORP5 and ORP8 is regulated by both PM PI4P and PI(4,5)P<sub>2</sub> Dynamic control of ORP5/8 recruitment to the PM occurs through intera ...[more]