MiR-23a binds to p53 and enhances its association with miR-128 promoter.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4639766 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
miR-23a binds to p53 and enhances its association with miR-128 promoter.
Li Jincheng J Aung Lynn Htet Htet LH Long Bo B Qin Danian D An Shejuan S Li Peifeng P
Scientific reports 20151110
Apoptosis plays an important role in cardiac pathology, but the molecular mechanism by which apoptosis regulated remains largely elusive. Here, we report that miR-23a promotes the apoptotic effect of p53 in cardiomyocytes. Our results showed that miR-23a promotes apoptosis induced by oxidative stress. In exploring the molecular mechanism by which miR-23a promotes apoptosis, we found that it sensitized the effect of p53 on miR-128 regulation. It promoted the association of p53 to the promoter reg ...[more]
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