Ontology highlight
ABSTRACT:
SUBMITTER: Balbi M
PROVIDER: S-EPMC4640303 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Balbi Matilde M Ghosh Mitrajit M Longden Thomas A TA Jativa Vega Max M Gesierich Benno B Hellal Farida F Lourbopoulos Athanasios A Nelson Mark T MT Plesnila Nikolaus N
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150610 9
Aging leads to a gradual decline in the fidelity of cerebral blood flow (CBF) responses to neuronal activation, resulting in an increased risk for stroke and dementia. However, it is currently unknown when age-related cerebrovascular dysfunction starts or which vascular components and functions are first affected. The aim of this study was to examine the function of microcirculation throughout aging in mice. Microcirculation was challenged by inhalation of 5% and 10% CO2 or by forepaw stimulatio ...[more]