Ontology highlight
ABSTRACT:
SUBMITTER: Satterlee AB
PROVIDER: S-EPMC4640695 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Satterlee Andrew B AB Yuan Hong H Huang Leaf L
Journal of controlled release : official journal of the Controlled Release Society 20150901
We have developed a theranostic nanoparticle delivering the model radionuclide (177)Lu based on the versatile lipid-calcium-phosphate (LCP) nanoparticle delivery platform. Characterization of (177)Lu-LCP has shown that radionuclide loading can be increased by several orders of magnitude without affecting the encapsulation efficiency or the morphology of (177)Lu-LCP, allowing consistency during fabrication and overcoming scale-up barriers typical of nanotherapeutics. The choice of (177)Lu as a mo ...[more]