Ontology highlight
ABSTRACT:
SUBMITTER: Kim W
PROVIDER: S-EPMC4641307 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Kim Wookhyun W Haller Carolyn C Dai Erbin E Wang Xiowei X Hagemeyer Christoph E CE Liu David R DR Peter Karlheinz K Chaikof Elliot L EL
Angewandte Chemie (International ed. in English) 20141210 5
Activated platelets provide a promising target for imaging inflammatory and thrombotic events along with site-specific delivery of a variety of therapeutic agents. Multifunctional protein micelles bearing targeting and therapeutic proteins were now obtained by one-pot transpeptidation using an evolved sortase A. Conjugation to the corona of a single-chain antibody (scFv), which binds to the ligand-induced binding site (LIBS) of activated GPIIb/IIIa receptors, enabled the efficient detection of t ...[more]