Ontology highlight
ABSTRACT:
SUBMITTER: Kim W
PROVIDER: S-EPMC3404820 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Kim Wookhyun W Brady Colin C Chaikof Elliot L EL
Acta biomaterialia 20120410 7
A variety of polymeric nanoparticles have been developed for bioimaging applications. This study reports on the use of a 50 nm recombinant protein nanoparticle with a multivalent surface as a vehicle for functionalization with a model imaging agent. Multiple fluorescent probes were covalently conjugated to surface amines of crosslinked amphiphilic elastin-mimetic protein micelles using N-hydroxysuccinimide ester chemistry. In vivo fluorescence imaging confirmed that protein micelles selectively ...[more]