Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC8599684 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Zhu Qian Q Huang Jinzhou J Huang Hongyang H Li Huan H Yi Peiqiang P Kloeber Jake A JA Yuan Jian J Chen Yuping Y Deng Min M Luo Kuntian K Gao Ming M Guo Guijie G Tu Xinyi X Yin Ping P Zhang Yong Y Su Jun J Chen Jiayi J Lou Zhenkun Z
Nature communications 20211117 1
BRCA1-BARD1 heterodimers act in multiple steps during homologous recombination (HR) to ensure the prompt repair of DNA double strand breaks. Dysfunction of the BRCA1 pathway enhances the therapeutic efficiency of poly-(ADP-ribose) polymerase inhibitors (PARPi) in cancers, but the molecular mechanisms underlying this sensitization to PARPi are not fully understood. Here, we show that cancer cell sensitivity to PARPi is promoted by the ring between ring fingers (RBR) protein RNF19A. We demonstrate ...[more]