Ontology highlight
ABSTRACT:
SUBMITTER: Miller LM
PROVIDER: S-EPMC4641566 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Miller Lisa M LM Gragg Megan M Kim Tae Gyun TG Park Paul S-H PS
FEBS letters 20150907 20 Pt B
Mutations in rhodopsin can cause misfolding and aggregation of the receptor, which leads to retinitis pigmentosa, a progressive retinal degenerative disease. The structure adopted by misfolded opsin mutants and the associated cell toxicity is poorly understood. Förster resonance energy transfer (FRET) and Fourier transform infrared (FTIR) microspectroscopy were utilized to probe within cells the structures formed by G188R and P23H opsins, which are misfolding mutants that cause autosomal dominan ...[more]