Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC4783658 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhou Jihan J Li Dong D Wen Hao H Zheng Shuquan S Su Cuicui C Yi Fan F Wang Jue J Liang Zicai Z Tang Tao T Zhou Demin D Zhang Li-He LH Liang Dehai D Du Quan Q
Scientific reports 20160309
Size-dependent passive targeting based on the characteristics of tissues is a basic mechanism of drug delivery. While the nanometer-sized particles are efficiently captured by the liver and spleen, the micron-sized particles are most likely entrapped within the lung owing to its unique capillary structure and physiological features. To exploit this property in lung-targeting siRNA delivery, we designed and studied a multi-domain peptide named K-β, which was able to form inter-molecular β-sheet s ...[more]