A structural biology perspective on NMDA receptor pharmacology and function.
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ABSTRACT:
SUBMITTER: Regan MC
PROVIDER: S-EPMC4641752 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
A structural biology perspective on NMDA receptor pharmacology and function.
Regan Michael C MC Romero-Hernandez Annabel A Furukawa Hiro H
Current opinion in structural biology 20150815
N-methyld-aspartate receptors (NMDARs) belong to the large family of ionotropic glutamate receptors (iGluRs), which are critically involved in basic brain functions as well as multiple neurological diseases and disorders. The NMDARs are large heterotetrameric membrane protein complexes. The extensive extracellular domains recognize neurotransmitter ligands and allosteric compounds and translate the binding information to regulate activity of the transmembrane ion channel. Here, we review recent ...[more]
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