Ontology highlight
ABSTRACT:
SUBMITTER: Liu LX
PROVIDER: S-EPMC4642527 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Liu Lan-Xiang LX Wang Xue-Quan XQ Zhou Bei B Yang Li-Juan LJ Li Yan Y Zhang Hong-Bin HB Yang Xiao-Dong XD
Scientific reports 20150819
A series of novel N-substituted carbazole imidazolium salt derivatives has been prepared and investigated for their cytotoxic activity against five human tumor cell lines by MTS assay. The results indicated that the existence of 5,6-dimethyl-benzimidazole ring, substitution of the imidazolyl-3-position with a 2-bromobenzyl or naphthylacyl group, as well as alkyl chain length between carbazole and imidazole ring were important for the antitumor activity. Compound 61, bearing a 2-bromobenzyl subst ...[more]