Ontology highlight
ABSTRACT:
SUBMITTER: Powers ME
PROVIDER: S-EPMC4642999 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Powers Michael E ME Becker Russell E N RE Sailer Anne A Turner Jerrold R JR Bubeck Wardenburg Juliane J
Cell host & microbe 20150601 6
Multi-organ failure contributes to mortality in bacterial sepsis. Platelet and immune cell activation contribute to organ injury during sepsis, but the mechanisms by which bacterial virulence factors initiate these responses remain poorly defined. We demonstrate that during lethal sepsis, Staphylococcus aureus α-toxin simultaneously alters platelet activation and promotes neutrophil inflammatory signaling through interactions with its cellular receptor ADAM10. Platelet intoxication prevents endo ...[more]