Ontology highlight
ABSTRACT:
SUBMITTER: Surewaard BGJ
PROVIDER: S-EPMC6295203 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Surewaard Bas G J BGJ Thanabalasuriar Ajitha A Zeng Zhutian Z Tkaczyk Christine C Cohen Taylor S TS Bardoel Bart W BW Jorch Selina K SK Deppermann Carsten C Bubeck Wardenburg Juliane J Davis Rachelle P RP Jenne Craig N CN Stover Kendall C KC Sellman Bret R BR Kubes Paul P
Cell host & microbe 20180719 2
During sepsis, small blood vessels can become occluded by large platelet aggregates of poorly understood etiology. During Staphylococcal aureus infection, sepsis severity is linked to the bacterial α-toxin (α-hemolysin, AT) through unclear mechanisms. In this study, we visualized intravascular events in the microcirculation and found that intravenous AT injection induces rapid platelet aggregation, forming dynamic micro-thrombi in the microcirculation. These aggregates are retained in the liver ...[more]