Ontology highlight
ABSTRACT:
SUBMITTER: Barnes CO
PROVIDER: S-EPMC4643057 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20150701 2
Notwithstanding numerous published structures of RNA Polymerase II (Pol II), structural details of Pol II engaging a complete nucleic acid scaffold have been lacking. Here, we report the structures of TFIIF-stabilized transcribing Pol II complexes, revealing the upstream duplex and full transcription bubble. The upstream duplex lies over a wedge-shaped loop from Rpb2 that engages its minor groove, providing part of the structural framework for DNA tracking during elongation. At the upstream tran ...[more]