Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

ABSTRACT: Alzheimer's disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since neuroinflammation is thought to play an important role in AD, we hypothesized that cytokines may play a direct role in promoting neuronal death. Here, we profiled cytokine expression in a small cohort of human AD and control brain tissues. We identified AD-associated cytokines using partial least squares regression to correlate cytokine expression with quantified pathologic disease state and then used neuron cultures to test whether cytokines up-regulated in AD tissues could affect neuronal viability. This analysis identified cytokines that were associated with the pathological s

SUBMITTER: Wood LB 

PROVIDER: S-EPMC4643219 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature