Ontology highlight
ABSTRACT:
SUBMITTER: Jeong C
PROVIDER: S-EPMC4643256 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Jeong Choongwon C Alkorta-Aranburu Gorka G Basnyat Buddha B Neupane Maniraj M Witonsky David B DB Pritchard Jonathan K JK Beall Cynthia M CM Di Rienzo Anna A
Nature communications 20140101
Admixture is recognized as a widespread feature of human populations, renewing interest in the possibility that genetic exchange can facilitate adaptations to new environments. Studies of Tibetans revealed candidates for high-altitude adaptations in the EGLN1 and EPAS1 genes, associated with lower haemoglobin concentration. However, the history of these variants or that of Tibetans remains poorly understood. Here we analyse genotype data for the Nepalese Sherpa, and find that Tibetans are a mixt ...[more]