Ontology highlight
ABSTRACT:
SUBMITTER: Peck EM
PROVIDER: S-EPMC4643739 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20150629 27
A macrocyclic tetralactam host is threaded by a highly fluorescent squaraine dye that is flanked by two polyethylene glycol (PEG) chains with nanomolar dissociation constants in water. Furthermore, the rates of bimolecular association are very fast with k(on) ≈ 10(6)-10(7) M(-1) s(-1). The association is effective under cell culture conditions and produces large changes in dye optical properties including turn-on near-infrared fluorescence that can be imaged using cell microscopy. Association co ...[more]