Ontology highlight
ABSTRACT:
SUBMITTER: Gallipoli P
PROVIDER: S-EPMC6061932 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Gallipoli Paolo P Giotopoulos George G Tzelepis Konstantinos K Costa Ana S H ASH Vohra Shabana S Medina-Perez Paula P Basheer Faisal F Marando Ludovica L Di Lisio Lorena L Dias Joao M L JML Yun Haiyang H Sasca Daniel D Horton Sarah J SJ Vassiliou George G Frezza Christian C Huntly Brian J P BJP
Blood 20180220 15
FLT3 internal tandem duplication (FLT3<sup>ITD</sup>) mutations are common in acute myeloid leukemia (AML) associated with poor patient prognosis. Although new-generation FLT3 tyrosine kinase inhibitors (TKI) have shown promising results, the outcome of FLT3<sup>ITD</sup> AML patients remains poor and demands the identification of novel, specific, and validated therapeutic targets for this highly aggressive AML subtype. Utilizing an unbiased genome-wide clustered regularly interspaced short pali ...[more]