Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
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ABSTRACT:
SUBMITTER: Richardson BG
PROVIDER: S-EPMC4643947 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.
Richardson B G BG Jain A D AD Speltz T E TE Moore T W TW
Bioorganic & medicinal chemistry letters 20150416 11
Nrf2 is the major transcription factor that regulates many of the cytoprotective enzymes involved in the adaptive stress response. Modulation of Nrf2 could be therapeutically useful in a number of disease states. Activation can occur through either an electrophilic or non-electrophilic mechanism. To date, most of the research has focused on electrophilic Nrf2 activators, but there is increasing interest in non-electrophilic modulators of Nrf2. This Digest examines the current selection of small ...[more]
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