Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.

ABSTRACT: Nrf2 is the major transcription factor that regulates many of the cytoprotective enzymes involved in the adaptive stress response. Modulation of Nrf2 could be therapeutically useful in a number of disease states. Activation can occur through either an electrophilic or non-electrophilic mechanism. To date, most of the research has focused on electrophilic Nrf2 activators, but there is increasing interest in non-electrophilic modulators of Nrf2. This Digest examines the current selection of small molecules that modulate Nrf2 through non-electrophilic mechanisms, and it highlights new opportunities for this important therapeutic target.

SUBMITTER: Richardson BG 

PROVIDER: S-EPMC4643947 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature