Ontology highlight
ABSTRACT:
SUBMITTER: Baird L
PROVIDER: S-EPMC7296212 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20200615 13
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by targeting it for ubiquitination and proteasome-dependent degradation. In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within KEAP1 allows NRF2 to escape ubiquitination, accumulate within the cell, and translocate ...[more]