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Spectrophotometric Investigations of Macrolide Antibiotics: A Brief Review.

ABSTRACT: Macrolides, one of the most commonly used class of antibiotics, are a group of drugs produced by Streptomyces species. They belong to the polyketide class of natural products. Their activity is due to the presence of a large macrolide lactone ring with deoxy sugar moieties. They are protein synthesis inhibitors and broad-spectrum antibiotics, active against both gram-positive and gram-negative bacteria. Different analytical techniques have been reported for the determination of macrolides such as chromatographic methods, flow injection methods, spectrofluorometric methods, spectrophotometric methods, and capillary electrophoresis methods. Among these methods, spectrophotometric methods are sensitive and cost effective for the analysis of various antibiotics in pharmaceutical formulations as well as biological samples. This article reviews different spectrophotometric methods for the determination of macrolide antibiotics.

SUBMITTER: Keskar MR

PROVIDER: S-EPMC4644142 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Spectrophotometric Investigations of Macrolide Antibiotics: A Brief Review.

Keskar Mrudul R MR Jugade Ravin M RM

Analytical chemistry insights 20151112

Macrolides, one of the most commonly used class of antibiotics, are a group of drugs produced by Streptomyces species. They belong to the polyketide class of natural products. Their activity is due to the presence of a large macrolide lactone ring with deoxy sugar moieties. They are protein synthesis inhibitors and broad-spectrum antibiotics, active against both gram-positive and gram-negative bacteria. Different analytical techniques have been reported for the determination of macrolides such a ...[more]

PMID: 26609215

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Project description:This comprehensive study addressed the occurrence, seasonal changes, removal efficiencies, and environmental risk assessments of three macrolide antibiotics in five wastewater treatment plants (WWTPs) with conventional and different additional treatment processes. A 1-year monitoring study was conducted, and influents and effluents were collected from Guangzhou (GZ), Shenzhen (SZ), Tai Po (TP), Shatin (ST), and Stonecutters Island (SI) WWTPs. Solid phase extraction and HPLC-MS/MS were used for the pretreatment and determination. The detection limits for azithromycin (AZI), erythromycin (ERY), and roxithromycin (ROX) ranged from 0.80 to 2.13 ng/L for the influent and effluent water samples. AZI was the most abundant antibiotic found in the influents, with average concentrations ranging from 571 ng/L to 1046 ng/L at all the target WWTPs. The seasonal average AZI concentration was the highest in all five WWTPs with the concentration of 984 ng/L in autumn, 849 ng/L in winter, 741 ng/L in summer, and 533 ng/L in spring. The seasonal AZI removal rates in the WWTPs were similar, with an average removal rate above 63.3% from spring to winter. All the treatments in the five WWTPs showed removal abilities for AZI, ERY, and ROX, regardless of the three phase treatments, namely, the UV disinfection process and conventional or chemically enhanced process within the WWTPs. For ERY and ROX, the average total removal rates were significantly decreased in the spring among all five WWTPs, at 53.1% and 57.8%, respectively. The GZ and SZ WWTPs displayed better removal rates than the TP, ST, and SI WWTPs, because the activity underlying the modified A2/O process in the GZ and SZ WWTPs has important effects on the antibiotic removal because the bacteria could produce compact granules and make the antibiotics settle faster in the wastewater. The additional UV disinfection in the SZ WWTP improved the removal efficiencies of the target antibiotics; it enhanced the biodegradability of residual organic pollutants in the WWTP effluent. Moreover, the corresponding environmental risks have been assessed and are viewed as a necessary component of future research.Supplementary informationThe online version contains supplementary material available at 10.1007/s11270-021-05053-y.

Dataset Information

Spectrophotometric Investigations of Macrolide Antibiotics: A Brief Review.

Publications

Spectrophotometric Investigations of Macrolide Antibiotics: A Brief Review.

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