Ontology highlight
ABSTRACT:
SUBMITTER: Creixell P
PROVIDER: S-EPMC4644237 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Creixell Pau P Palmeri Antonio A Miller Chad J CJ Lou Hua Jane HJ Santini Cristina C CC Nielsen Morten M Turk Benjamin E BE Linding Rune R
Cell 20150917 1
Protein kinases control cellular responses to environmental cues by swift and accurate signal processing. Breakdowns in this high-fidelity capability are a driving force in cancer and other diseases. Thus, our limited understanding of which amino acids in the kinase domain encode substrate specificity, the so-called determinants of specificity (DoS), constitutes a major obstacle in cancer signaling. Here, we systematically discover several DoS and experimentally validate three of them, named the ...[more]