MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization.
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ABSTRACT:
SUBMITTER: Millard LA
PROVIDER: S-EPMC4644974 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization.
Millard Louise A C LA Davies Neil M NM Timpson Nic J NJ Tilling Kate K Flach Peter A PA Davey Smith George G
Scientific reports 20151116
Observational cohort studies can provide rich datasets with a diverse range of phenotypic variables. However, hypothesis-driven epidemiological analyses by definition only test particular hypotheses chosen by researchers. Furthermore, observational analyses may not provide robust evidence of causality, as they are susceptible to confounding, reverse causation and measurement error. Using body mass index (BMI) as an exemplar, we demonstrate a novel extension to the phenome-wide association study ...[more]
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