Ontology highlight
ABSTRACT:
SUBMITTER: Ali M
PROVIDER: S-EPMC4645621 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Ali Muzaffar M Daze Kevin D KD Strongin Daniel E DE Rothbart Scott B SB Rincon-Arano Hector H Allen Hillary F HF Li Janessa J Strahl Brian D BD Hof Fraser F Kutateladze Tatiana G TG
The Journal of biological chemistry 20150730 38
Plant homeodomain (PHD) finger-containing proteins are implicated in fundamental biological processes, including transcriptional activation and repression, DNA damage repair, cell differentiation, and survival. The PHD finger functions as an epigenetic reader that binds to posttranslationally modified or unmodified histone H3 tails, recruiting catalytic writers and erasers and other components of the epigenetic machinery to chromatin. Despite the critical role of the histone-PHD interaction in n ...[more]