Ontology highlight
ABSTRACT:
SUBMITTER: Jain K
PROVIDER: S-EPMC6979384 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Jain Kanishk K Fraser Caroline S CS Marunde Matthew R MR Parker Madison M MM Sagum Cari C Burg Jonathan M JM Hall Nathan N Popova Irina K IK Rodriguez Keli L KL Vaidya Anup A Krajewski Krzysztof K Keogh Michael-Christopher MC Bedford Mark T MT Strahl Brian D BD
Epigenetics & chromatin 20200124 1
<h4>Background</h4>Plant homeodomain (PHD) fingers are central "readers" of histone post-translational modifications (PTMs) with > 100 PHD finger-containing proteins encoded by the human genome. Many of the PHDs studied to date bind to unmodified or methylated states of histone H3 lysine 4 (H3K4). Additionally, many of these domains, and the proteins they are contained in, have crucial roles in the regulation of gene expression and cancer development. Despite this, the majority of PHD fingers ha ...[more]