Ontology highlight
ABSTRACT:
SUBMITTER: Remesh SG
PROVIDER: S-EPMC4646024 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Remesh Soumya G SG Santosh Vishaka V Escalante Carlos R CR
The Journal of biological chemistry 20150924 46
IRF4 is a unique member of the interferon regulatory factor (IRF) family playing critical regulatory roles in immune cell development, regulation of obesity-induced inflammation, and control of thermogenic gene expression. The ability of IRF4 to control diverse transcriptional programs arises from its proficiency to interact with numerous transcriptional partners. In this study, we present the structural characterization of full-length IRF4. Using a combination of x-ray and small angle x-ray sca ...[more]