Ontology highlight
ABSTRACT:
SUBMITTER: Gong L
PROVIDER: S-EPMC4646234 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Gong Lihu L Liu Min M Zeng Tu T Shi Xiaoli X Yuan Cai C Andreasen Peter A PA Huang Mingdong M
The Journal of biological chemistry 20150831 43
Thrombosis is a leading cause of death worldwide. Recombinant tissue-type plasminogen activator (tPA) is the Food and Drug Administration-approved thrombolytic drug. tPA is rapidly inactivated by endogenous plasminogen activator inhibitor-1 (PAI-1). Engineering on tPA to reduce its inhibition by PAI-1 without compromising its thrombolytic effect is a continuous effort. Precise details, with atomic resolution, of the molecular interactions between tPA and PAI-1 remain unknown despite previous ext ...[more]