Ontology highlight
ABSTRACT:
SUBMITTER: Hargrove AE
PROVIDER: S-EPMC4646452 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20151116 11
Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significantly downregulates AR driven gene expression. Polyamide exposure to VCaP cells reduced proliferation without causing DNA damage. Py-Im polyamide treatment also reduced tumor growth in a VCaP mouse xen ...[more]