Ontology highlight
ABSTRACT:
SUBMITTER: Langen M
PROVIDER: S-EPMC4646663 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cell 20150625 1
Complicated neuronal circuits can be genetically encoded, but the underlying developmental algorithms remain largely unknown. Here, we describe a developmental algorithm for the specification of synaptic partner cells through axonal sorting in the Drosophila visual map. Our approach combines intravital imaging of growth cone dynamics in developing brains of intact pupae and data-driven computational modeling. These analyses suggest that three simple rules are sufficient to generate the seemingly ...[more]