Dataset Information

Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow.

ABSTRACT: Continuous monitoring of variations in blood flow is vital in assessing the status of microvascular and macrovascular beds for a wide range of clinical and research scenarios. Although a variety of techniques exist, most require complete immobilization of the subject, thereby limiting their utility to hospital or clinical settings. Those that can be rendered in wearable formats suffer from limited accuracy, motion artifacts, and other shortcomings that follow from an inability to achieve intimate, noninvasive mechanical linkage of sensors with the surface of the skin. We introduce an ultrathin, soft, skin-conforming sensor technology that offers advanced capabilities in continuous and precise blood flow mapping. Systematic work establishes a set of experimental procedures and theoretical models for quantitative measurements and guidelines in design and operation. Experimental studies on human subjects, including validation with measurements performed using state-of-the-art clinical techniques, demonstrate sensitive and accurate assessment of both macrovascular and microvascular flow under a range of physiological conditions. Refined operational modes eliminate long-term drifts and reduce power consumption, thereby providing steps toward the use of this technology for continuous monitoring during daily activities.

SUBMITTER: Webb RC

PROVIDER: S-EPMC4646823 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow.

Webb R Chad RC Ma Yinji Y Krishnan Siddharth S Li Yuhang Y Yoon Stephen S Guo Xiaogang X Feng Xue X Shi Yan Y Seidel Miles M Cho Nam Heon NH Kurniawan Jonas J Ahad James J Sheth Niral N Kim Joseph J Taylor James G JG Darlington Tom T Chang Ken K Huang Weizhong W Ayers Joshua J Gruebele Alexander A Pielak Rafal M RM Slepian Marvin J MJ Huang Yonggang Y Gorbach Alexander M AM Rogers John A JA

Science advances 20151030 9

Continuous monitoring of variations in blood flow is vital in assessing the status of microvascular and macrovascular beds for a wide range of clinical and research scenarios. Although a variety of techniques exist, most require complete immobilization of the subject, thereby limiting their utility to hospital or clinical settings. Those that can be rendered in wearable formats suffer from limited accuracy, motion artifacts, and other shortcomings that follow from an inability to achieve intimat ...[more]

PMID: 26601309

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Project description:SignificanceThe accurate large-scale mapping of cerebral microvascular blood flow velocity is crucial for a better understanding of cerebral blood flow (CBF) regulation. Although optical imaging techniques enable both high-resolution microvascular angiography and fast absolute CBF velocity measurements in the mouse cortex, they usually require different imaging techniques with independent system configurations to maximize their performances. Consequently, it is still a challenge to accurately combine functional and morphological measurements to co-register CBF speed distribution from hundreds of microvessels with high-resolution microvascular angiograms.AimWe propose a data acquisition and processing framework to co-register a large set of microvascular blood flow velocity measurements from dynamic light scattering optical coherence tomography (DLS-OCT) with the corresponding microvascular angiogram obtained using two-photon microscopy (2PM).ApproachWe used DLS-OCT to first rapidly acquire a large set of microvascular velocities through a sealed cranial window in mice and then to acquire high-resolution microvascular angiograms using 2PM. The acquired data were processed in three steps: (i) 2PM angiogram coregistration with the DLS-OCT angiogram, (ii) 2PM angiogram segmentation and graphing, and (iii) mapping of the CBF velocities to the graph representation of the 2PM angiogram.ResultsWe implemented the developed framework on the three datasets acquired from the mice cortices to facilitate the coregistration of the large sets of DLS-OCT flow velocity measurements with 2PM angiograms. We retrieved the distributions of red blood cell velocities in arterioles, venules, and capillaries as a function of the branching order from precapillary arterioles and postcapillary venules from more than 1000 microvascular segments.ConclusionsThe proposed framework may serve as a useful tool for quantitative analysis of large microvascular datasets obtained by OCT and 2PM in studies involving normal brain functioning, progression of various diseases, and numerical modeling of the oxygen advection and diffusion in the realistic microvascular networks.

Dataset Information

Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow.

Publications

Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow.

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