Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC4647833 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Xu Jing J Li Zhongshan Z Ren Xianguo X Dong Ming M Li Jinxin J Shi Xingjuan X Zhang Yu Y Xie Wei W Sun Zhongsheng Z Liu Xiangdong X Dai Qiming Q
Scientific reports 20151117
Hypertrophic cardiomyopathy (HCM) is a cardiovascular disease with high heterogeneity. Limited knowledge concerning the genetic background of nearly 40% HCM cases indicates there is a clear need for further investigation to explore the genetic pathogenesis of the disease. In this study, we undertook a whole exome sequencing (WES) approach to identify novel candidate genes and mutations associated with HCM. The cohort consisted of 74 unrelated patients with sporadic HCM (sHCM) previously determin ...[more]