Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
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ABSTRACT:
SUBMITTER: Clancy KW
PROVIDER: S-EPMC4648256 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
Clancy Kathleen W KW Melvin Jeffrey A JA McCafferty Dewey G DG
Biopolymers 20100101 4
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase. ...[more]
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