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Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.


ABSTRACT: Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.

SUBMITTER: Clancy KW 

PROVIDER: S-EPMC4648256 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.

Clancy Kathleen W KW   Melvin Jeffrey A JA   McCafferty Dewey G DG  

Biopolymers 20100101 4


Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase. ...[more]

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