Ontology highlight
ABSTRACT:
SUBMITTER: Pozhidaeva A
PROVIDER: S-EPMC6481172 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Pozhidaeva Alexandra A Bezsonova Irina I
DNA repair 20190216
Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS). Components of this pathway, including the proteasome, ubiquitinating enzymes and deubiquitinating enzymes, are highly specialized and tightly regulated. In this mini-review we focus on the de-ubiquitinating enzyme USP7, and summarize latest advances in understanding its structure, substrate specificity and relevance to human cancers. There is increasing interest in UPS components as targets for cancer therapy and he ...[more]