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USP7: Structure, substrate specificity, and inhibition.


ABSTRACT: Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS). Components of this pathway, including the proteasome, ubiquitinating enzymes and deubiquitinating enzymes, are highly specialized and tightly regulated. In this mini-review we focus on the de-ubiquitinating enzyme USP7, and summarize latest advances in understanding its structure, substrate specificity and relevance to human cancers. There is increasing interest in UPS components as targets for cancer therapy and here we also overview the recent progress in the development of small molecule inhibitors that target USP7.

SUBMITTER: Pozhidaeva A 

PROVIDER: S-EPMC6481172 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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USP7: Structure, substrate specificity, and inhibition.

Pozhidaeva Alexandra A   Bezsonova Irina I  

DNA repair 20190216


Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS). Components of this pathway, including the proteasome, ubiquitinating enzymes and deubiquitinating enzymes, are highly specialized and tightly regulated. In this mini-review we focus on the de-ubiquitinating enzyme USP7, and summarize latest advances in understanding its structure, substrate specificity and relevance to human cancers. There is increasing interest in UPS components as targets for cancer therapy and he  ...[more]

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