Ontology highlight
ABSTRACT:
SUBMITTER: Harris RJ
PROVIDER: S-EPMC4648305 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Harris Robert J RJ Cloughesy Timothy F TF Liau Linda M LM Prins Robert M RM Antonios Joseph P JP Li Debiao D Yong William H WH Pope Whitney B WB Lai Albert A Nghiemphu Phioanh L PL Ellingson Benjamin M BM
Neuro-oncology 20150624 11
<h4>Background</h4>Interstitial tissue acidosis resulting from abnormal perfusion and metabolism is a hallmark of cancer. The current study demonstrates that chemical exchange saturation transfer (CEST) MRI can be used as a noninvasive pH-weighted molecular imaging technique by targeting the chemical exchange between amine protons and protons in extracellular bulk water.<h4>Methods</h4>First, the sensitivity of amine CEST was validated in phantoms under a variety of conditions, including differe ...[more]