Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts.
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ABSTRACT:
SUBMITTER: Millard SM
PROVIDER: S-EPMC4649292 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts.
Millard Susan M SM Pettit Allison R AR Ellis Rebecca R Chan Jerry K Y JKY Raggatt Liza J LJ Khosrotehrani Kiarash K Fisk Nicholas M NM
Stem cell reports 20151029 5
In this article, Millard and colleagues show that intrauterine bone marrow transplantation in the oim/oim mouse model of osteogenesis imperfecta yields hematopoietic microchimerism in the absence of donor osteopoiesis or phenotypic improvement. Bone-associated donor cells were not bone-forming osteoblasts, but osteoclasts (bone resorbing cells of the hematopoietic lineage) and osteal macrophages (bone regulatory cells of the hematopoietic lineage). ...[more]
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