An Efficient Genome-Wide Multilocus Epistasis Search.
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ABSTRACT:
SUBMITTER: Karkkainen HP
PROVIDER: S-EPMC4649656 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
An Efficient Genome-Wide Multilocus Epistasis Search.
Kärkkäinen Hanni P HP Li Zitong Z Sillanpää Mikko J MJ
Genetics 20150923 3
There has been a continuing interest in approaches that analyze pairwise locus-by-locus (epistasis) interactions using multilocus association models in genome-wide data sets. In this paper, we suggest an approach that uses sure independence screening to first lower the dimension of the problem by considering the marginal importance of each interaction term within the huge loop. Subsequent multilocus association steps are executed using an extended Bayesian least absolute shrinkage and selection ...[more]
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