Ontology highlight
ABSTRACT:
SUBMITTER: Thakkar S
PROVIDER: S-EPMC4649741 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Scientific reports 20151118
Atherosclerosis related cardiovascular diseases continue to be the primary cause of mortality in developed countries. The elevated level of low density lipoprotein (LDL) is generally considered to be the driver of atherosclerosis, but recent years have seen a shift in this perception in that the vascular plaque buildup is mainly caused by oxidized LDL (ox-LDL) rather than native-LDL. The scavenger receptor LOX-1 found in endothelial cells binds and internalizes ox-LDL which leads to the initiati ...[more]