Unknown

Dataset Information

0

Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis.

ABSTRACT: We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.

SUBMITTER: Cabibbe AM 

PROVIDER: S-EPMC4652106 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis.

Cabibbe Andrea M AM   Miotto Paolo P   Moure Raquel R   Alcaide Fernando F   Feuerriegel Silke S   Pozzi Gianni G   Nikolayevskyy Vladislav V   Drobniewski Francis F   Niemann Stefan S   Reither Klaus K   Cirillo Daniela M DM  

Journal of clinical microbiology 20150805 12

We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use. ...[more]

Similar Datasets

Unknown Lab-on-a-Film disposable for genotyping multidrug-resistant Mycobacterium tuberculosis from sputum extracts.
| S-EPMC6461559 | biostudies-literature
Unknown From chip-in-a-lab to lab-on-a-chip: a portable Coulter counter using a modular platform.
| S-EPMC6240576 | biostudies-literature
Unknown Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform.
| S-EPMC7224984 | biostudies-literature
Unknown Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria.
| S-EPMC7955031 | biostudies-literature
Unknown A lab-on-chip for malaria diagnosis and surveillance.
| S-EPMC4029813 | biostudies-other
Unknown Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolates from China.
| S-EPMC4023728 | biostudies-literature
Unknown Molecular Diagnosis of Drug-Resistant Tuberculosis; A Literature Review.
| S-EPMC6477542 | biostudies-literature
Unknown An Electromechanical Lab-on-a-Chip Platform for Colorimetric Detection of Serum Creatinine.
| S-EPMC9330075 | biostudies-literature
Unknown Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus).
| S-EPMC5816666 | biostudies-literature
Unknown Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain.
| S-EPMC2631879 | biostudies-other