Ontology highlight
ABSTRACT:
SUBMITTER: DePaul MA
PROVIDER: S-EPMC4652166 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
DePaul Marc A MA Palmer Marc M Lang Bradley T BT Cutrone Rochelle R Tran Amanda P AP Madalena Kathryn M KM Bogaerts Annelies A Hamilton Jason A JA Deans Robert J RJ Mays Robert W RW Busch Sarah A SA Silver Jerry J
Scientific reports 20151119
Following spinal cord injury (SCI), immune-mediated secondary processes exacerbate the extent of permanent neurological deficits. We investigated the capacity of adult bone marrow-derived stem cells, which exhibit immunomodulatory properties, to alter inflammation and promote recovery following SCI. In vitro, we show that human multipotent adult progenitor cells (MAPCs) have the ability to modulate macrophage activation, and prior exposure to MAPC secreted factors can reduce macrophage-mediated ...[more]