Ontology highlight
ABSTRACT:
SUBMITTER: Kim JB
PROVIDER: S-EPMC4687687 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
The EMBO journal 20151023 23
The generation of patient-specific oligodendrocyte progenitor cells (OPCs) holds great potential as an expandable cell source for cell replacement therapy as well as drug screening in spinal cord injury or demyelinating diseases. Here, we demonstrate that induced OPCs (iOPCs) can be directly derived from adult mouse fibroblasts by Oct4-mediated direct reprogramming, using anchorage-independent growth to ensure high purity. Homogeneous iOPCs exhibit typical small-bipolar morphology, maintain thei ...[more]