Ontology highlight
ABSTRACT:
SUBMITTER: Bhaskar U
PROVIDER: S-EPMC4652654 | biostudies-literature | 2015 Sep-Oct
REPOSITORIES: biostudies-literature
Bhaskar Ujjwal U Hickey Anne M AM Li Guoyun G Mundra Ruchir V RV Zhang Fuming F Fu Li L Cai Chao C Ou Zhimin Z Dordick Jonathan S JS Linhardt Robert J RJ
Biotechnology progress 20150716 5
The contamination crisis of 2008 has brought to light several risks associated with use of animal tissue derived heparin. Because the total chemical synthesis of heparin is not feasible, a bioengineered approach has been proposed, relying on recombinant enzymes derived from the heparin/HS biosynthetic pathway and Escherichia coli K5 capsular polysaccharide. Intensive process engineering efforts are required to achieve a cost-competitive process for bioengineered heparin compared to commercially ...[more]