Ontology highlight
ABSTRACT:
SUBMITTER: Iwama E
PROVIDER: S-EPMC4653018 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Iwama Eiji E Takayama Koichi K Harada Taishi T Okamoto Isamu I Ookubo Fumihiko F Kishimoto Junji J Baba Eishi E Oda Yoshinao Y Nakanishi Yoichi Y
Oncotarget 20150801 24
The mutation of T790M in EGFR is a major mechanism of resistance to treatment with EGFR-TKIs. Only qualitative detection (presence or absence) of T790M has been described to date, however. Digital PCR (dPCR) analysis has recently been applied to the quantitative detection of target molecules in cancer with high sensitivity. In the present study, 25 tumor samples (13 obtained before and 12 after EGFR-TKI treatment) from 18 NSCLC patients with activating EGFR mutations were evaluated for T790M wit ...[more]