Ontology highlight
ABSTRACT:
SUBMITTER: Kiskinis E
PROVIDER: S-EPMC4653065 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kiskinis Evangelos E Sandoe Jackson J Williams Luis A LA Boulting Gabriella L GL Moccia Rob R Wainger Brian J BJ Han Steve S Peng Theodore T Thams Sebastian S Mikkilineni Shravani S Mellin Cassidy C Merkle Florian T FT Davis-Dusenbery Brandi N BN Ziller Michael M Oakley Derek D Ichida Justin J Di Costanzo Stefania S Atwater Nick N Maeder Morgan L ML Goodwin Mathew J MJ Nemesh James J Handsaker Robert E RE Paull Daniel D Noggle Scott S McCarroll Steven A SA Joung J Keith JK Woolf Clifford J CJ Brown Robert H RH Eggan Kevin K
Cell stem cell 20140403 6
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neuronal degeneration. Here, we have combined reprogramming and stem cell differentiation approaches with genome engineering and RNA sequencing to define the transcriptional and functional changes that are induced in human motor neurons by mutant SOD1. Muta ...[more]